Abstract This is a rare case report of an extensive squamous cell carcinoma in situ of the endometrium (ESCC-I) in a 79-year-old nulliparous female that was diagnosed incidentally following hysterectomy due to her prolapsed uterus. The progression of ESCC-I was consistent with the cephalic spread from a cervical high-grade intraepithelial lesion/squamous cell carcinoma in situ. Both lesions were confirmed to have developed through a human papillomavirus (HPV) driven mechanism (p16, p40, HPV-16 positive). The clinical, histopathological and molecular studies are discussed along with review of the literature.
Keywords: HPV; human papilloma virus; endometrial squamous cell carcinoma; endometrial cancer